Behind the science – Of Eucerin Hyaluron-Filler

Skin’s structure changes as we age: fine lines and wrinkles appear first and deepen over time. As we continue to mature skin’s volume and firmness, radiance and, later on, its elasticity all gradually reduce.

The Eucerin Hyaluron-Filler range has been specially formulated to address the first signs of aging such as fine lines and wrinkles. Eucerin’s unique blend of high and low molecular Hyaluronic Acid and Glycine Saponin delivers a targeted approach to visibly plumping even the deepest wrinkles for a rejuvenated look.

“Most of us start to develop fine lines and wrinkles in our early 30s,” explains Dr Sven Fey, R&D Category Head at Eucerin. Skin aging, like aging in general, is inevitable and there are several different factors that govern it. There’s little we can do about the internal, biological factors such as our genetics and our hormones, but we can take lifestyle steps to avoid and reduce some of the external factors that speed up the aging process: and the most significant to those is over-exposure to the sun.

“Some 90% of premature aging is caused by the sun,” says Dr Fey. “When we set out to create the Eucerin Hyaluron-Filler range, we wanted to protect skin from sun damage as well as to create a formula that would give skin the hydration it needs and plump up deep wrinkles.”

With more than 100 years of clinical experience and expertise, and products that are proven to deliver results, Eucerin is a trusted brand amongst dermatologists worldwide. “94% of the dermatologists we spoke to1 said that they found Hyaluron injections the most versatile way to deal with skin-aging concerns,” explains Dr Fey. “We wanted to create a topical, skincare formula that would offer the wrinkle-filling benefits of Hyaluronic Acid without the need for invasive treatment or, alternatively, support the results of dermatologist-led treatments.”

Research began on how to maximize the benefits of Hyaluronic Acid in a topical formula. “Hyaluronic Acid is a powerful moisturizer,” says Dr Fey. Produced naturally in young skin our cells produce less Hyaluronic Acid as we age: skin becomes drier (sometimes referred to as age-induced dryness) and fine lines and wrinkles become more visible on skin’s surface. “We combined two types of Hyaluronic Acid – high and low molecular - in the Eucerin Hyaluron-Filler formula for maximum benefits.” explains Dr Fey.

• High molecular Hyaluronic Acid remains on skin’s surface and works to improve hydration in the outermost layer of the epidermis – where fine lines and winkles originate. 
• With molecules that are 40 times smaller² than those of high molecular Hyaluronic Acid, Low molecular Hyaluronic Acid penetrates further into the epidermal layers where it stimulates skin’s own production of Hyaluronic Acid.

High molecular Hyaluronic Acid

Low molecular Hyaluronic Acid

“Using both molecular weights means that the formula addresses surface fine lines and deeper wrinkles, “says Dr. Fey, “but we didn’t just stop there”. Dr Fey and his team went on to enhance the effectiveness of the Hyaluronic Acid by adding Glycine Saponin to the formula. An extract of the soya bean it is, as he explains, “one of the most effective stimulators of Hyaluronic Acid in the dermal layers of skin”. It’s been independently proven to increase Hyaluronic Acid production in skin cells by up to 256%³.

Beiersdorf In vitro research: Saponins – A New Generation of Hyaluronan-Stimulating Actives for Human Skin S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H.Wenck Beiersdorf AG, Hamburg, Germany

The team then worked with their base formula to add superior UVB and UVA filters to create day cream offering sun protection: Hyaluron- Filler Day SPF 15 for dry skin.

To enhance the benefits of the day, night and eye creams focus turned to the development of a Concentrate and a dual-efficacy overnight treatment. This latest innovation, Eucerin Hyaluron-Filler Overnight Treatment has been formulated to exfoliate and refine skin texture. “It’s a double chamber product and unique in anti-aging skincare “explains Dr Fey. “The gel formula in the first chamber contains both high and low molecular Hyaluronic Acid⁴, while the emulsion in the other chamber contains Glycine Saponin and an effective AHA (alpha-hydroxy-acid) Complex for exfoliation. AHAs are commonly known as Fruit Acids.” When combined together the gel and emulsion promote skin cell renewal and refine skin while plumping up even the deepest wrinkles. “We recommend that, for best results, you use it prior Eucerin Hyaluron-Filler Night Cream” adds Dr Fey.

The range is clinically and dermatologically proven to plump up even the deepest wrinkles for a rejuvenated look.

Research includes Product-in-use (PIU) studies on the SPF 15 day creams^5,6, the eye cream⁵, the Overnight Treatment⁸ and the night cream⁵. All studies were conducted amongst regular users of anti-aging products who reported the following impressive results after two weeks of use:

Eucerin Hyaluron-Filler Day SPF 15 for dry skin:

• 84%: prevents the formation of fine lines and wrinkles 
• 96%: long-lasting protection from skin drying out - 84%: leaves skin visibly and noticeably smoother
• 90%: an ideal make-up base 

Eucerin Hyaluron-Filler Eye Cream:

• 85%: slows down the development and appearance of wrinkles
• 87%: prevents the formation of fine lines and wrinkles
• 90%: an ideal make-up base

Eucerin Hyaluron-Filler Overnight Treatment:

• 96%: refines skin texture
• 95%: provides radiant skin
• 93%: noticeably smoother skin
• 93%: makes my skin more radiant
• 91%: the product has a lifting effect
• 91%: refines the appearance of my pores 
• 91%: makes my skin feel firmer
• 91%: noticeably improves the appearance of my skin

Eucerin Hyaluron-Filler Night Cream:

• 82%: visibly reduces fine lines
• 84%: prevents the formation of fine lines and wrinkles
• 90%: leaves skin visibly and noticeably smoother

“These results, as well as results from other clinical and dermatological studies, prove the efficacy of our products,” concludes Dr. Fey. “Eucerin Hyaluron-Filler helps women to address the first signs of aging without invasive treatment and can also be used in conjunction with dermatological treatments to support and extend results.”

1. Beiersdorf research: Non-representative survey among 250 dermatologists from Central and Eastern Europe, Argentina, France, Thailand, Germany and Chile
2. The standard unit for measuring the mass of an atom is a kilo Dalton (kDa). Long-chained Hyaluronic Acid has a kDa of 2000 and short-chained Hyaluronic Acid has a kDa of 52.
3. Study report: Saponins – a new generation of Hyaluronan-stimulating actives for human skin, S. Gallinat, F. Rippke, C. Keppler, J. Mergell, A. Bürger, F. Stäb, H. Wenck Beiersdorf AG, Hamburg, Germany
4. High molecular Hyaluronic Acid improves hydration and smooths the outermost layers of skin while low molecular Hyaluronic Acid (which is 40 times smaller than the low molecular Hyaluronic Acid in the formula) penetrates further into the epidermal skin layers where deeper wrinkles originate.
5. Beiersdorf AG, PiU, June 2010. Research sample: 126 women (50% 30-39 years of age)
6. Beiersdorf AG, PiU, October 2010. Research sample: 120 women (50% 30 –39 years of age)
7. Beiersdorf AG, PiU, February 2015. Research sample: 160 women aged between 34 and 45
8. Beiersdorf AG, PiU, March 2018. Research sample: 150 women aged between 35 and 55
9. After 8 weeks of treatment with Hyaluron-Filler Day or Night (proven for each formula), Efficacy of two new anti-wrinkle face care creams with Saponin and Hyaluronic Acid A. Burger, U. Scherdin, U. Koop, S. Gallinat, M. Moers-Carpi, M. Carpi, J. Mergell, F. Rippke |